| First Author | Duan B | Year | 2007 |
| Journal | Lab Invest | Volume | 87 |
| Issue | 1 | Pages | 14-28 |
| PubMed ID | 17170739 | Mgi Jnum | J:117043 |
| Mgi Id | MGI:3695508 | Doi | 10.1038/labinvest.3700497 |
| Citation | Duan B, et al. (2007) Lupus resistance is associated with marginal zone abnormalities in an NZM murine model. Lab Invest 87(1):14-28 |
| abstractText | The NZM2410 and NZM TAN (TAN) are two of 27 inbred strains derived from an intercross between the NZW and NZB strains. NZM2410 mice develop a highly penetrant lupus nephritis mediated by three susceptibility loci, Sle1, Sle2 and Sle3. These three loci have been combined on a C57BL/6 background in a triple congenic strain that reconstitutes the NZM2410 autoimmune phenotype. Remarkably, inspite of the presence of Sle1, Sle2 and Sle3, TAN mice display a mild autoimmune phenotype reminiscent of NZW. Contrary to the lupus-prone strains, the majority of TAN CD4(+) T cells are in a naive-inactivated stage. TAN mice show B-cell developmental abnormalities similar to lupus-prone mice, such an accumulation of transitional T1 cells and peritoneal B-1a cells. TAN mice show, however, a unique expansion of the splenic marginal zone, in which B cells express high levels of CD5 and CD9, fail to migrate to the follicles in response to LPS, and show sub-optimal binding of T-independent type 2 antigens. Therefore, TAN mice present a functional silencing of marginal zone B cells, which have been previously implicated with autoimmune process. The TAN strain thus provides a novel model for the analysis of the genetic determinants of B-cell autoreactivity.Laboratory Investigation (2007) 87, 14-28. doi:10.1038/labinvest.3700497; published online 27 November 2006. |
