| First Author | Freeman LJ | Year | 2005 |
| Journal | Biochem J | Volume | 388 |
| Issue | Pt 1 | Pages | 1-5 |
| PubMed ID | 15790312 | Mgi Jnum | J:117501 |
| Mgi Id | MGI:3696618 | Doi | 10.1042/BJ20050368 |
| Citation | Freeman LJ, et al. (2005) Fibulin-5 interacts with fibrillin-1 molecules and microfibrils. Biochem J 388(Pt 1):1-5 |
| abstractText | Fibulin-5 plays an important role in elastic fibre formation in vivo. We have investigated the molecular interactions between fibulin-5 and components of fibrillin-rich microfibrils which form a template for elastin. Fibulin-5 interacted in a dose-dependent manner with a fibrillin-1 N-terminal sequence and with tropoelastin, but not with MAGP-1 (microfibril-associated glycoprotein-1) or decorin. Fibulin-5 did not inhibit interactions between fibrillin-1 N- and C-terminal fragments, or fibrillin-1 interactions with tropoelastin. Fibulin-5 may provide a link between tropoelastin and microfibrils in the pericellular space during elastic fibre assembly. |
