| First Author | Nie X | Year | 2006 |
| Journal | Angle Orthod | Volume | 76 |
| Issue | 6 | Pages | 990-5 |
| PubMed ID | 17090159 | Mgi Jnum | J:117768 |
| Mgi Id | MGI:3697559 | Doi | 10.2319/082305-298 |
| Citation | Nie X (2006) Developmentally regulated expression of MSX1, MSX2 and Fgfs in the developing mouse cranial base. Angle Orthod 76(6):990-5 |
| abstractText | OBJECTIVE: To examine the expression pattern of the Fgf and Msx genes in cranial base development. MATERIALS AND METHODS: To detect the expression of these genes, antisense riboprobes were synthesized by in vitro transcription. Radioactive in situ hybridization was performed on parasagittal sections of embryonic mouse heads. RESULTS: Msx2 was observed in the underlying perichondrium at restricted stages. Msx1 was not observed in cranial base development. Fgf1 was localized in osteogenic cells from the time of ossification; Fgf10 was highly expressed in the occipital-vertebral joint during E13 to E14; Fgf2, Fgf7, and Fgf18 were localized in the perichondria; Fgf12 was transitorily expressed at early chondrocranium; Fgf9 was seen in the hypertrophic chondrocytes. CONCLUSIONS: The Fgf and Msx gene expression in the cranial base was different from that of other skeletons. |
