| First Author | Nakata M | Year | 2007 |
| Journal | Biochem Biophys Res Commun | Volume | 353 |
| Issue | 4 | Pages | 1046-51 |
| PubMed ID | 17207771 | Mgi Jnum | J:117844 |
| Mgi Id | MGI:3697796 | Doi | 10.1016/j.bbrc.2006.12.134 |
| Citation | Nakata M, et al. (2007) Resistin induces insulin resistance in pancreatic islets to impair glucose-induced insulin release. Biochem Biophys Res Commun 353(4):1046-51 |
| abstractText | An adipokine resistin, a small cysteine-rich protein, is one of the major risk factors of insulin resistance. In the present study, transiently resistin-expressing mice using adenovirus method showed an impaired glucose tolerance due to insulin resistance. We found that resistin-expressing mice exhibited impaired insulin secretory response to glucose. In addition, in vitro treatment with resistin for 1 day induced insulin resistance in pancreatic islets and impaired glucose-stimulated insulin secretion by elevating insulin release at basal glucose (2.8mM) and suppressing insulin release at stimulatory glucose (8.3mM). In addition, resistin inhibited insulin-induced phosphorylation of Akt in islets as well as other insulin target organs. Furthermore, resistin induced SOCS-3 expression in beta-cells. In conclusion, resistin induces insulin resistance in islet beta-cells at least partly via induction of SOCS-3 expression and reduction of Akt phosphorylation and impairs glucose-induced insulin secretion. |
