| First Author | Gibot S | Year | 2007 |
| Journal | Eur J Immunol | Volume | 37 |
| Issue | 2 | Pages | 456-66 |
| PubMed ID | 17230441 | Mgi Jnum | J:117877 |
| Mgi Id | MGI:3697944 | Doi | 10.1002/eji.200636387 |
| Citation | Gibot S, et al. (2007) TREM-1 promotes survival during septic shock in mice. Eur J Immunol 37(2):456-66 |
| abstractText | Triggering receptor expressed on myeloid (TREM)-1 is integral to the inflammatory response occurring during septic shock, although its precise function has yet to be determined. Here we show that in vivo silencing of TREM-1 using siRNA duplexes in a fecal peritonitis mouse model resulted in a blunted inflammatory response and increased mortality. This was associated with impaired bacterial clearance related to marked inhibition of the neutrophil oxidative burst. By contrast, TREM-1-silenced mice were highly resistant to a lethal endotoxin challenge, while partial silencing of TREM-1 in the bacterial peritonitis model produced a significant survival benefit. These data highlight the crucial role of the TREM-1 pathway in mounting an adequate inflammatory and cytotoxic response to polymicrobial sepsis, and both the therapeutic promise and potential risks of its modulation. |
