| First Author | Clarke CJ | Year | 2006 |
| Journal | Biochim Biophys Acta | Volume | 1758 |
| Issue | 12 | Pages | 1893-901 |
| PubMed ID | 16938269 | Mgi Jnum | J:117969 |
| Mgi Id | MGI:3698109 | Doi | 10.1016/j.bbamem.2006.06.025 |
| Citation | Clarke CJ, et al. (2006) Neutral sphingomyelinases and nSMase2: bridging the gaps. Biochim Biophys Acta 1758(12):1893-901 |
| abstractText | There is strong evidence indicating a role for ceramide as a second messenger in processes such as apoptosis, cell growth and differentiation, and cellular responses to stress. Ceramide formation from the hydrolysis of sphingomyelin is considered to be a major pathway of stress-induced ceramide production with magnesium-dependent neutral sphingomyelinase (N-SMase) identified as a prime candidate in this pathway. The recent cloning of a mammalian N-SMase-nSMase2- and generation of nSMase2 knockout/mutant mice have now provided vital tools with which to further study the regulation and roles of this enzyme in both a physiological and pathological context. In the present review, we summarize current knowledge on N-SMase relating this to what is known about nSMase2. We also discuss the future areas of nSMase2 research important for molecular understanding of this enzyme and its physiological roles. |
