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Publication : Selective expression of Bhlhb5 in subsets of early-born interneurons and late-born association neurons in the spinal cord.

First Author  Liu B Year  2007
Journal  Dev Dyn Volume  236
Issue  3 Pages  829-35
PubMed ID  17219401 Mgi Jnum  J:118347
Mgi Id  MGI:3699460 Doi  10.1002/dvdy.21061
Citation  Liu B, et al. (2007) Selective expression of Bhlhb5 in subsets of early-born interneurons and late-born association neurons in the spinal cord. Dev Dyn 236(3):829-35
abstractText  Accumulating evidence has suggested that the basic helix-loop-helix transcription factors play important roles in controlling neuronal fate specification and differentiation in the developing central nervous system. In this study, we report a detailed immunological study on the expression of Bhlhb5 in embryonic mouse spinal cord with a newly developed antibody. At the early stage of neural development, Bhlhb5 is specifically expressed in dI6 dorsal interneurons and in V1 and V2 ventral interneurons. At late stages of development, Bhlhb5 expression is detected in a subset of late-born dorsal association interneurons that migrate into the uppermost layer of the dorsal horn. Developmental Dynamics 236:829-835, 2007. (c) 2007 Wiley-Liss, Inc.
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