| First Author | Kim SH | Year | 2002 |
| Journal | J Clin Invest | Volume | 110 |
| Issue | 11 | Pages | 1675-86 |
| PubMed ID | 12464673 | Mgi Jnum | J:118423 |
| Mgi Id | MGI:3699561 | Doi | 10.1172/JCI15547 |
| Citation | Kim SH, et al. (2002) CCR4-bearing T cells participate in autoimmune diabetes. J Clin Invest 110(11):1675-86 |
| abstractText | Chemokine receptor expression is exquisitely regulated on T cell subsets during the course of their migration to inflammatory sites. In the present study we demonstrate that CCR4 expression marks a pathogenic population of autoimmune T cells. CCR4 was found exclusively on memory CD4(+) T cells during the progression of disease in NOD mice. Cells expressing the CCR4 ligand TARC (thymus- and activation-regulated chemokine) were detected within infiltrated islets from prediabetic mice. Interestingly, neutralization of macrophage-derived chemokine (MDC) with Ab caused a significant reduction of CCR4-positive T cells within the pancreatic infiltrates and inhibited the development of insulitis and diabetes. Furthermore, enhanced recruitment of CCR4-bearing cells in NOD mice resulting from transgenic expression of MDC resulted in acceleration of clinical disease. Cumulatively, the results demonstrate that CCR4-bearing T cells participate in the development of such tissue-driven autoimmune reactions. |
