| First Author | Wang H | Year | 2003 |
| Journal | J Immunol | Volume | 171 |
| Issue | 12 | Pages | 6381-8 |
| PubMed ID | 14662836 | Mgi Jnum | J:118458 |
| Mgi Id | MGI:3699640 | Doi | 10.4049/jimmunol.171.12.6381 |
| Citation | Wang H, et al. (2003) Evidence for a ligand-mediated positive selection signal in differentiation to a mature B cell. J Immunol 171(12):6381-8 |
| abstractText | Positive selection is required for B cell differentiation, as indicated by the requirement for expression of the pre-B cell receptor (pre-BCR) and the BCR at the pre-B and immature B cell stages, respectively. Positive selection mediated by a tonic signal from these receptors is sufficient to drive B cell differentiation beyond the pre-B and immature B cell stages, but it is unclear whether additional positive selection signals are required for differentiation to a mature B-2 cell. We have identified a population of Ig transgenic B cells that differentiatively arrest at a transitional B cell stage in the spleen. They exhibit no evidence of Ag encounter or negative selection and can differentiate to mature B-2 cells in vivo upon weak BCR stimulation or adoptive transfer to irradiated hosts. These data are consistent with a requirement for a ligand-mediated BCR signal for differentiation to a mature B-2 cell. |
