| First Author | Breloer M | Year | 2007 |
| Journal | Eur J Immunol | Volume | 37 |
| Issue | 3 | Pages | 634-48 |
| PubMed ID | 17266176 | Mgi Jnum | J:118687 |
| Mgi Id | MGI:3700107 | Doi | 10.1002/eji.200636852 |
| Citation | Breloer M, et al. (2007) CD83 is a regulator of murine B cell function in vivo. Eur J Immunol 37(3):634-48 |
| abstractText | The transmembrane glycoprotein CD83 has been described as a specific maturation marker for dendritic cells and several lines of evidence suggest that CD83 regulates thymic T cell maturation as well as peripheral T cell activation. Here we show for the first time that CD83 is involved also in the regulation of B cell function. CD83 is up-regulated on activated B cells in vivo, specifically in the draining lymph nodes of Leishmania major-infected mice. The ubiquitous transgenic (Tg) expression of CD83 interferes with Leishmania-specific T cell-dependent and with T cell-independent antibody production. This defect is restricted to the B cell population since the antigen-specific T cell response of CD83Tg mice to L. major infection is unchanged. The defective immunoglobulin (Ig) response is due to Tg expression of CD83 on the B cells because wild-type B cells display normal antigen-specific responses in CD83Tg hosts and CD83Tg B cells do not respond to immunization in a mixed wild-type/CD83Tg bone marrow chimera. Finally, the treatment of non-Tg C57BL/6 mice with anti-CD83 mAb induces a dramatic increase in the antigen-specific IgG response to immunization, thus demonstrating a regulatory role for naturally induced CD83 on wild-type B cells. |
