| First Author | Spear BT | Year | 2006 |
| Journal | Cell Mol Life Sci | Volume | 63 |
| Issue | 24 | Pages | 2922-38 |
| PubMed ID | 17041810 | Mgi Jnum | J:119246 |
| Mgi Id | MGI:3701579 | Doi | 10.1007/s00018-006-6258-5 |
| Citation | Spear BT, et al. (2006) Transcriptional control in the mammalian liver: liver development, perinatal repression, and zonal gene regulation. Cell Mol Life Sci 63(24):2922-38 |
| abstractText | Liver function is crucial for maintaining metabolic homeostasis in mammals. Numerous genes must be properly regulated for the liver to develop and perform a variety of activities. Several recent gene-knockout studies in mice have clarified the roles of GATA6, HNF4alpha, and Foxa1/Foxa2 in early stages of liver formation. After the liver forms, transcriptional changes continue to occur; during the perinatal period, certain genes such as alpha-fetoprotein and H19 are silenced, others are activated, and position-dependent (or zonal) regulation is established. Zhx2 was recently identified as one factor involved in postnatal repression of alpha-fetoprotein and other genes. Furthermore, several studies indicate that negative regulation is involved in the zonal control of glutamine synthetase. Finally, exciting new evidence indicates that signaling through the Wnt/beta-catenin pathway is also involved in zonal regulation in the adult liver. |
