| First Author | Kubo KY | Year | 2007 |
| Journal | Neurosci Lett | Volume | 414 |
| Issue | 2 | Pages | 188-91 |
| PubMed ID | 17207572 | Mgi Jnum | J:119406 |
| Mgi Id | MGI:3702061 | Doi | 10.1016/j.neulet.2006.12.020 |
| Citation | Kubo KY, et al. (2007) Occlusal disharmony induces spatial memory impairment and hippocampal neuron degeneration via stress in SAMP8 mice. Neurosci Lett 414(2):188-91 |
| abstractText | We examined the effect of occlusal disharmony in senescence-accelerated (SAMP8) mice on plasma corticosterone levels, hippocampal neuron number, and spatial performance in the water maze. The bite-raised condition was associated with an accelerated age-related decline in spatial memory, increased plasma corticosterone levels, and a decreased number of neurons in the hippocampal CA3 region. The findings suggest that the bite-raised condition in aged SAMP8 mice induces hippocampal neuron loss, thereby leading to senile memory deficits. |
