| First Author | Rodriguez M | Year | 1995 |
| Journal | J Neurovirol | Volume | 1 |
| Issue | 1 | Pages | 111-7 |
| PubMed ID | 9222347 | Mgi Jnum | J:30515 |
| Mgi Id | MGI:78024 | Doi | 10.3109/13550289509111015 |
| Citation | Rodriguez M, et al. (1995) H-2 Dd transgene suppresses Theiler's virus-induced demyelination in susceptible strains of mice. J Neurovirol 1(1):111-7 |
| abstractText | Theiler's murine encephalomyelitis virus is a picornavirus which induces chronic immune-mediated central nervous system demyelination and virus persistence in susceptible strains of mice. Using murine strains with congeneic recombinant haplotypes, the H-2D region within the class I major histocompatibility complex has been shown to be important in determining susceptibility/resistance to chronic Theiler's murine encephalomyelitis virus infection. We examined the role of H-2D in demyelinating disease with the use of transgenic D8 mice (H-2Dd, resistant haplotype) crossed to susceptible B10.Q (H-2q) and B10.S (H-2s) mice. Expression of the H-2Dd transgene dramatically suppressed demyelination and reduced the number of virus-antigen positive cells in the spinal cord 45 days following infection. More complete protection was observed in transgenic B10.Q (D8+) mice than in transgenic B10.S (D8+) mice. These experiments support the hypothesis that the immunologic basis of resistance by H-2D is determined by effective antigen presentation which prevents virus persistence and subsequent demyelination. |
