| First Author | Chang SY | Year | 2007 |
| Journal | Neuroscience | Volume | 145 |
| Issue | 3 | Pages | 1026-36 |
| PubMed ID | 17291689 | Mgi Jnum | J:121646 |
| Mgi Id | MGI:3710895 | Doi | 10.1016/j.neuroscience.2006.12.054 |
| Citation | Chang SY, et al. (2007) Age and gender-dependent alternative splicing of P/Q-type calcium channel EF-hand. Neuroscience 145(3):1026-36 |
| abstractText | Ca(v)2.1 Ca(2+) channels (P/Q-type), which participate in various key roles in the CNS by mediating calcium influx, are extensively spliced. One of its alternatively-spliced exons is 37, which forms part of the EF hand. The expression of exon 37a (EFa form), but not exon 37b (EFb form), confers the channel an activity-dependent enhancement of channel opening known as Ca(2+)-dependent facilitation (CDF). In this study, we analyzed the trend of EF hand splice variant distributions in mouse, rat and human brain tissues. We observed a developmental switch in rodents, as well as an age and gender bias in human brain tissues, suggestive of a possible role of these EF hand splice variants in neurophysiological specialization. A parallel study performed on rodent brains showed that the data drawn from human and rodent tissues may not necessarily correlate in the process of aging. |
