| First Author | Kasugai M | Year | 2007 |
| Journal | Biochem Biophys Res Commun | Volume | 357 |
| Issue | 4 | Pages | 1078-83 |
| PubMed ID | 17467670 | Mgi Jnum | J:121767 |
| Mgi Id | MGI:3711597 | Doi | 10.1016/j.bbrc.2007.04.067 |
| Citation | Kasugai M, et al. (2007) Differences in two mice strains on kainic acid-induced amygdalar seizures. Biochem Biophys Res Commun 357(4):1078-83 |
| abstractText | Seizure susceptibility and neurodegeneration induced by microinjection of kainic acid (KA) into the left amygdala (LA) in C57BL/6 and FVB/N mouse strains were compared. Mice were administered 0.5 microg of KA into the LA. Electroencephalograms (EEGs) and behavior were monitored for 48 h after KA microinjection. Neuronal cell damages in the CA1 and CA3 regions of hippocampus were assessed at 2 and 48 h after KA microinjection. We demonstrated that the FVB/N mice showed longer duration of seizure activity than the C57BL/6 mice in EEGs and behavioral observation. The C57BL/6 mice were resistant to neurodegeneration while the FVB/N mice were vulnerable as measured 2 and 48 h after KA microinjection. These differences might be associated with genetic background. |
