| First Author | Ekkens MJ | Year | 2007 |
| Journal | Infect Immun | Volume | 75 |
| Issue | 5 | Pages | 2291-6 |
| PubMed ID | 17325050 | Mgi Jnum | J:121872 |
| Mgi Id | MGI:3712582 | Doi | 10.1128/IAI.01328-06 |
| Citation | Ekkens MJ, et al. (2007) Th1 and Th2 cells help CD8 T-cell responses. Infect Immun 75(5):2291-6 |
| abstractText | Help from CD4 T cells is often important for the establishment of primary and memory CD8 T-cell responses. However, it has yet to be determined whether T helper polarization affects the delivery of help and/or whether responding CD8 T cells helped by Th1 or Th2 cells express distinct effector properties. To address these issues, we compared CD8 T-cell responses in the context of Th1 or Th2 help by injecting dendritic cells copulsed with the major histocompatibility complex class I-restricted OVA peptide plus, respectively, bacterial or helminth antigens. We found that Th2 cells, like Th1 cells, can help primary and long-lived memory CD8 T-cell responses. Experiments in interleukin-12 (IL-12)-/- and IL-4-/- mice, in which polarized Th1 or Th2 responses, respectively, fail to develop, indicate that the underlying basis of CD4 help is independent of attributes acquired as a response to polarization. |
