| First Author | Lunyak VV | Year | 2007 |
| Journal | Science | Volume | 317 |
| Issue | 5835 | Pages | 248-51 |
| PubMed ID | 17626886 | Mgi Jnum | J:122928 |
| Mgi Id | MGI:3715997 | Doi | 10.1126/science.1140871 |
| Citation | Lunyak VV, et al. (2007) Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis. Science 317(5835):248-51 |
| abstractText | The temporal and spatial regulation of gene expression in mammalian development is linked to the establishment of functional chromatin domains. Here, we report that tissue-specific transcription of a retrotransposon repeat in the murine growth hormone locus is required for gene activation. This repeat serves as a boundary to block the influence of repressive chromatin modifications. The repeat element is able to generate short, overlapping Pol II-and Pol III-driven transcripts, both of which are necessary and sufficient to enable a restructuring of the regulated locus into nuclear compartments. These data suggest that transcription of interspersed repetitive sequences may represent a developmental strategy for the establishment of functionally distinct domains within the mammalian genome to control gene activation. |
