| First Author | Heisler LK | Year | 2006 |
| Journal | Neuron | Volume | 51 |
| Issue | 2 | Pages | 239-49 |
| PubMed ID | 16846858 | Mgi Jnum | J:122967 |
| Mgi Id | MGI:3716036 | Doi | 10.1016/j.neuron.2006.06.004 |
| Citation | Heisler LK, et al. (2006) Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron 51(2):239-49 |
| abstractText | The neural pathways through which central serotonergic systems regulate food intake and body weight remain to be fully elucidated. We report that serotonin, via action at serotonin1B receptors (5-HT1BRs), modulates the endogenous release of both agonists and antagonists of the melanocortin receptors, which are a core component of the central circuitry controlling body weight homeostasis. We also show that serotonin-induced hypophagia requires downstream activation of melanocortin 4, but not melanocortin 3, receptors. These results identify a primary mechanism underlying the serotonergic regulation of energy balance and provide an example of a centrally derived signal that reciprocally regulates melanocortin receptor agonists and antagonists in a similar manner to peripheral adiposity signals. |
