| First Author | Ferrari F | Year | 2007 |
| Journal | Mol Cell Neurosci | Volume | 34 |
| Issue | 3 | Pages | 343-54 |
| PubMed ID | 17254795 | Mgi Jnum | J:123208 |
| Mgi Id | MGI:3717507 | Doi | 10.1016/j.mcn.2006.11.015 |
| Citation | Ferrari F, et al. (2007) The fragile X mental retardation protein-RNP granules show an mGluR-dependent localization in the post-synaptic spines. Mol Cell Neurosci 34(3):343-54 |
| abstractText | The localization of RNA/mRNA in dendrites plays a role in both local and temporal regulation of protein synthesis, which is required for certain forms of synaptic plasticity. A key molecule in these processes is the fragile X mental retardation protein (FMRP). Using in situ hybridization coupled to immunofluorescence confocal microscopy, we find that the FMRP-RNP particle contains alphaCaMKII and BC1 RNAs as well as Staufen and CPEB proteins. Furthermore, following mGluR activation, the FMRP-mRNP complex moves into spines as shown by co-localization with the PSD-95 and Shank proteins. This study shows, for the first time, that the translationally inactive FMRP-mRNP complex relocates into neuronal spines after stimulation and that de novo protein synthesis mainly contributes to the pool of FMRP at synapses. |
