| First Author | Zuluaga S | Year | 2007 |
| Journal | FEBS Lett | Volume | 581 |
| Issue | 20 | Pages | 3819-25 |
| PubMed ID | 17658519 | Mgi Jnum | J:123720 |
| Mgi Id | MGI:3719328 | Doi | 10.1016/j.febslet.2007.06.078 |
| Citation | Zuluaga S, et al. (2007) p38alpha MAPK can positively or negatively regulate Rac-1 activity depending on the presence of serum. FEBS Lett 581(20):3819-3825 |
| abstractText | The small GTP-ase Rac-1 can trigger p38 MAPK activation and, in turn, p38alpha can regulate signalling pathways that potentially impinge on Rac-1 activity. We have investigated the cross-talk between p38alpha and Rac-1 and found that p38alpha regulates the association between Rac-1 and caveolin-1 in serum-deprived cardiomyocytes. This interaction depends on cell attachment and correlates with higher levels of active Rac-1. Actin organization might regulate the formation of Rac-1-caveolin-1 complexes. In contrast, the Rac-1-caveolin-1 interaction is almost undetectable in the presence of serum, where Rac-1 activity is negatively regulated by p38alpha. Our results indicate that p38alpha can differentially contribute to Rac-1 activation depending on the presence of serum. |
