| First Author | Feldmeyer L | Year | 2007 |
| Journal | Curr Biol | Volume | 17 |
| Issue | 13 | Pages | 1140-5 |
| PubMed ID | 17600714 | Mgi Jnum | J:124166 |
| Mgi Id | MGI:3720991 | Doi | 10.1016/j.cub.2007.05.074 |
| Citation | Feldmeyer L, et al. (2007) The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes. Curr Biol 17(13):1140-5 |
| abstractText | It has long been known that human keratinocytes are a potent source of the proinflammatory cytokines proIL-1alpha and -1beta[1], which are activated and released in response to UV irradiation [2]. However, the intracellular pathways, which regulate maturation and secretion of IL-1 in keratinocytes, are unknown. Here we show that the UVB-mediated enhancement of cytoplasmic Ca(2+) is required for activation of the IL-1beta-converting enzyme caspase-1 by the inflammasome, a multiprotein innate immune complex [3, 4]. Caspase-1 in turn activates proIL-1beta, and keratinocytes secrete the cytokine as well as inflammasome components. These results demonstrate the presence of a proIL-1beta-processing inflammasome in nonprofessional immune cells and the necessity of inflammasome components for the UVB-induced secretion of IL-1beta. This supports the concept that keratinocytes are important immuno-competent cells under physiological and pathological conditions [5]. |
