| First Author | Eiseler T | Year | 2007 |
| Journal | FEBS Lett | Volume | 581 |
| Issue | 22 | Pages | 4279-87 |
| PubMed ID | 17707375 | Mgi Jnum | J:125167 |
| Mgi Id | MGI:3757793 | Doi | 10.1016/j.febslet.2007.07.079 |
| Citation | Eiseler T, et al. (2007) PKD is recruited to sites of actin remodelling at the leading edge and negatively regulates cell migration. FEBS Lett 581(22):4279-87 |
| abstractText | Protein kinase D (PKD) has been implicated in the regulation of cell shape, adhesion, and migration. At the leading edge of migrating cells active PKD co-localizes with F-actin, Arp3 and cortactin. Platelet derived growth factor (PDGF) activates PKD and recruits the kinase to the leading edge, suggesting a role for PKD in actin remodelling. In support of this, PKD directly interacts with F-actin and phosphorylates cortactin in vitro. Interference with PKD function by overexpression of a dominant negative PKD or by PKD-specific siRNA enhanced cell migration, whereas cells overexpressing PKD wild type displayed reduced migratory potential. Taken together, these data reveal a negative regulatory function of PKD in cell migration. |
