| First Author | Chang JT | Year | 2000 |
| Journal | J Immunol | Volume | 164 |
| Issue | 1 | Pages | 100-6 |
| PubMed ID | 10604999 | Mgi Jnum | J:125973 |
| Mgi Id | MGI:3760316 | Doi | 10.4049/jimmunol.164.1.100 |
| Citation | Chang JT, et al. (2000) Role of costimulation in the induction of the IL-12/IL-12 receptor pathway and the development of autoimmunity. J Immunol 164(1):100-6 |
| abstractText | Costimulation mediated by the interactions of the B7 Ags (CD80/CD86) on APC with CD28 on the responding T cell regulates the magnitude of the immune response and may influence Th1/Th2 development. The IL-12Rbeta2 subunit plays a critical role in maintaining IL-12 responsiveness and controlling Th1 lineage commitment. We demonstrate that IL-2 and IL-12 resulting from CD28/B7 interactions both play a critical role in the induction of expression of the IL-12Rbeta2 subunit and as a result the differentiation of pathogenic autoreactive effector cells. These findings suggest that targeting IL-2 and IL-12 simultaneously may be effective in the treatment of Th1-mediated autoimmunity. |
