| First Author | Pasparakis M | Year | 2006 |
| Journal | Cell Death Differ | Volume | 13 |
| Issue | 5 | Pages | 861-72 |
| PubMed ID | 16470223 | Mgi Jnum | J:126294 |
| Mgi Id | MGI:3760957 | Doi | 10.1038/sj.cdd.4401870 |
| Citation | Pasparakis M, et al. (2006) Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice. Cell Death Differ 13(5):861-72 |
| abstractText | Studies in transgenic and knockout mice have made a major contribution to our current understanding of the physiological functions of the NF-kappaB signalling cascade. The generation and analysis of mice with targeted modifications of individual components of the NF-kappaB pathway tremendously advanced our knowledge of the roles of the NF-kappaB proteins themselves, and also of the many activators and negative regulators of NF-kappaB. These studies have highlighted the complexity of the NF-kappaB system, by revealing the multiple interactions, redundancies, but also diverse functions, performed by the different molecules participating in the regulation of NF-kappaB signalling. Furthermore, inhibition or enforced activation of NF-kappaB in transgenic mice has uncovered the critical roles that NF-kappaB plays in the pathogenesis of various diseases such as liver failure, diabetes and cancer. |
