| First Author | Gerhauser I | Year | 2007 |
| Journal | J Neuroimmunol | Volume | 188 |
| Issue | 1-2 | Pages | 86-94 |
| PubMed ID | 17599467 | Mgi Jnum | J:128875 |
| Mgi Id | MGI:3768214 | Doi | 10.1016/j.jneuroim.2007.05.019 |
| Citation | Gerhauser I, et al. (2007) Ets-1 represents a pivotal transcription factor for viral clearance, inflammation, and demyelination in a mouse model of multiple sclerosis. J Neuroimmunol 188(1-2):86-94 |
| abstractText | Demyelination of Theiler's murine encephalomyelitis (TME) depends on viral persistence and on the mouse genotype. Ets-1 expression, a transcription factor involved in T cell activation and cytokine expression, was investigated in the spinal cord during TME using RT-qPCR and immunohistochemistry. Resistant C57BL/6 mice lacking virus persistence and demyelination demonstrated a stronger upregulation of Ets-1 mRNA transcripts in the early phase of TME compared to susceptible SJL/J mice probably linked to viral clearance. Though strong Ets-1 expression in resident glial cells such as astrocytes might inhibit lesion development, delayed Ets-1 activation in inflammatory cells seemed to promote demyelination in the late phase of TME in SJL/J mice. |
