| First Author | Klotz L | Year | 2007 |
| Journal | J Neuroimmunol | Volume | 190 |
| Issue | 1-2 | Pages | 34-43 |
| PubMed ID | 17719655 | Mgi Jnum | J:128968 |
| Mgi Id | MGI:3768448 | Doi | 10.1016/j.jneuroim.2007.07.017 |
| Citation | Klotz L, et al. (2007) Brain endothelial PPARgamma controls inflammation-induced CD4+ T cell adhesion and transmigration in vitro. J Neuroimmunol 190(1-2):34-43 |
| abstractText | An important step in the pathogenesis of multiple sclerosis is adhesion and transmigration of encephalitogenic T cells across brain endothelial cells (EC) which strongly relies on interaction with EC-expressed adhesion molecules. We provide molecular evidence that the transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma) is a negative regulator of brain EC inflammation. The PPARgamma agonist pioglitazone reduces transendothelial migration of encephalitogenic T cells across TNFalpha-stimulated brain EC. This effect is clearly PPARgamma mediated, as lentiviral PPARgamma overexpression in brain EC results in selective abrogation of inflammation-induced ICAM-1 and VCAM-1 upregulation and subsequent adhesion and transmigration of T cells. We therefore propose that PPARgamma in brain EC may be exploited to target detrimental EC-T cell interactions under inflammatory conditions. |
