| First Author | Kurita M | Year | 2004 |
| Journal | Biochem Biophys Res Commun | Volume | 324 |
| Issue | 2 | Pages | 554-61 |
| PubMed ID | 15474462 | Mgi Jnum | J:129003 |
| Mgi Id | MGI:3768483 | Doi | 10.1016/j.bbrc.2004.09.083 |
| Citation | Kurita M, et al. (2004) Overexpression of CR/periphilin downregulates Cdc7 expression and induces S-phase arrest. Biochem Biophys Res Commun 324(2):554-61 |
| abstractText | Cdc7 expression repressor (CR)/periphilin has been originally cloned as an interactor with periplakin, a precursor of the cornified cell envelope, and suggested to constitute a new type of nuclear matrix. We here show that CR/periphilin is a ubiquitously expressed nuclear protein with speckled distribution. Overexpression of CR/periphilin induces S-phase arrest. Analysis of expression of regulators involved in DNA replication has revealed that both mRNA and protein expression of Cdc7, a regulator of the initiation and continuation of DNA replication, are markedly downregulated by overexpression of CR/periphilin. However, co-expression of Cdc7 only marginally rescues S-phase arrest induced by CR, indicating that CR retards S-phase progression by modifying expression of some genes including Cdc7, which are involved in progression of DNA replication or coordination of DNA replication and S-phase progression. |
