| First Author | Underwood TJ | Year | 2007 |
| Journal | FEBS Lett | Volume | 581 |
| Issue | 30 | Pages | 5831-5 |
| PubMed ID | 18053811 | Mgi Jnum | J:129199 |
| Mgi Id | MGI:3768871 | Doi | 10.1016/j.febslet.2007.11.056 |
| Citation | Underwood TJ, et al. (2007) Dissection of the functional interaction between p53 and the embryonic proto-oncoprotein PAX3. FEBS Lett 581(30):5831-5 |
| abstractText | Studies from murine embryogenesis and cancer cells derived from human melanomas have identified a critical role for the transcription factor PAX3 in the suppression of p53 protein accumulation and p53-dependent apoptosis. Here we show, using a well-defined over-expression system, that PAX3 suppresses p53-dependent transcription from promoters of p53-responsive genes, notably BAX and HDM2-P2, and reduces p53 protein abundance by promoting its degradation. We define the functional domains of PAX3 required for this activity, and furthermore present evidence that PAX3-dependent inhibition of p53 is independent of binding of the N-terminal domain of p53 to HDM2, the primary negative regulator of cellular p53 activity. |
