| First Author | Yokoyama S | Year | 2008 |
| Journal | Gene Expr Patterns | Volume | 8 |
| Issue | 3 | Pages | 155-60 |
| PubMed ID | 18077221 | Mgi Jnum | J:130588 |
| Mgi Id | MGI:3771938 | Doi | 10.1016/j.gep.2007.11.001 |
| Citation | Yokoyama S, et al. (2008) Dynamic gene expression of Lin-28 during embryonic development in mouse and chicken. Gene Expr Patterns 8(3):155-60 |
| abstractText | The Caenorhabditis elegans heterochronic gene lin-28 regulates developmental timing in the nematode trunk. We report the dynamic expression patterns of Lin-28 homologues in mouse and chick embryos. Whole mount in situ hybridization revealed specific and intriguing expression patterns of Lin-28 in the developing mouse and chick limb bud. Mouse Lin-28 expression was detected in both the forelimb and hindlimb at E9.5, but disappeared from the forelimb at E10.5, and finally from the forelimb and hindlimb at E11.5. Chicken Lin-28, which was first detected in the limb primordium at stage 15/16, was also downregulated as the stage proceeded. The amino acid sequences of mouse and chicken Lin-28 genes are highly conserved and the similar expression patterns of Lin-28 during limb development in mouse and chicken suggest that this heterochronic gene is also conserved during vertebrate limb development. |
