| First Author | Lin KB | Year | 2008 |
| Journal | Immunity | Volume | 28 |
| Issue | 1 | Pages | 75-87 |
| PubMed ID | 18191594 | Mgi Jnum | J:131149 |
| Mgi Id | MGI:3773084 | Doi | 10.1016/j.immuni.2007.11.019 |
| Citation | Lin KB, et al. (2008) The rap GTPases regulate B cell morphology, immune-synapse formation, and signaling by particulate B cell receptor ligands. Immunity 28(1):75-87 |
| abstractText | B lymphocytes spread and extend membrane processes when searching for antigens and form immune synapses upon contacting cells that display antigens on their surface. Although these dynamic morphological changes facilitate B cell activation, the signaling pathways underlying these processes are not fully understood. We found that activation of the Rap GTPases was essential for these changes in B cell morphology. Rap activation was important for B cell receptor (BCR)- and lymphocyte-function-associated antigen-1 (LFA-1)-induced spreading, for BCR-induced immune-synapse formation, and for particulate BCR ligands to induce localized F-actin assembly and membrane-process extension. Rap activation and F-actin assembly were also required for optimal BCR signaling in response to particulate antigens but not soluble antigens. Thus by controlling B cell morphology and cytoskeletal organization, Rap might play a key role in the activation of B cells by particulate and cell-associated antigens. |
