| First Author | Lalonde R | Year | 2005 |
| Journal | Brain Res Bull | Volume | 66 |
| Issue | 2 | Pages | 155-62 |
| PubMed ID | 15982533 | Mgi Jnum | J:131588 |
| Mgi Id | MGI:3774026 | Doi | 10.1016/j.brainresbull.2005.04.015 |
| Citation | Lalonde R, et al. (2005) Exploratory activity and motor coordination in wild-type SOD1/SOD1 transgenic mice. Brain Res Bull 66(2):155-62 |
| abstractText | SOD1 is one of several overexpressed genes in trisomy 21. In order to dissect possible genetic causes of the syndrome, wild-type SOD1/SOD1 transgenic mice were compared to FVB/N non-transgenic controls at 5 months of age in tests of exploratory activity and motor coordination. Wild-type SOD1/SOD1 transgenic mice had fewer stereotyped movements in an open-field and fell sooner from a rotorod than controls. In contrast, wild-type SOD1/SOD1 transgenic mice had fewer falls on a wire suspension test. There was no intergroup difference for ambulatory movements in the open-field, exploration of the elevated plus-maze, emergence from a small compartment, and motor coordination on a stationary beam. These results indicate that homozygous mice expressing human SOD1 are impaired in their ability to adjust their posture in response to a moving surface and make fewer small-amplitude movements without any change in general exploratory activity. |
