| First Author | Park CH | Year | 2008 |
| Journal | FEBS Lett | Volume | 582 |
| Issue | 5 | Pages | 537-42 |
| PubMed ID | 18242186 | Mgi Jnum | J:131846 |
| Mgi Id | MGI:3774714 | Doi | 10.1016/j.febslet.2008.01.018 |
| Citation | Park CH, et al. (2008) Proneural bHLH neurogenin 2 differentially regulates Nurr1-induced dopamine neuron differentiation in rat and mouse neural precursor cells in vitro. FEBS Lett 582(5):537-542 |
| abstractText | Roles of Nurr1 and neurogenin 2 (Ngn2) have been shown in midbrain dopamine (DA) neuron development. We present here rat and mouse species-dependent differences of Nurr1 and Ngn2 actions in DA neuron differentiation. Nurr1 exogene expression caused an efficient generation of tyrosine hydroxylase (TH)-positive DA cells from rat neural precursor cells (NPCs). Nurr1-induced TH+ cell yields were low and highly variable depending on the origins of NPCs in mouse cultures. Coexpression of Ngn2 repressed Nurr1-induced generation of TH+ cells in rat cultures. In clear contrast, a robust enhancement in Nurr1-induced DA cell yields was observed in mouse NPCs by Ngn2. These findings imply that DA neurons may develop differently in the midbrains of these two species. |
