| First Author | Kuehl WM | Year | 2008 |
| Journal | Cancer Cell | Volume | 13 |
| Issue | 2 | Pages | 85-7 |
| PubMed ID | 18242508 | Mgi Jnum | J:131917 |
| Mgi Id | MGI:3774815 | Doi | 10.1016/j.ccr.2008.01.022 |
| Citation | Kuehl WM (2008) Modeling multiple myeloma by AID-dependent conditional activation of MYC. Cancer Cell 13(2):85-7 |
| abstractText | Efforts to create a mouse model that provides even a phenocopy of human multiple myeloma (MM) have been unsuccessful. In this issue of Cancer Cell, Bergsagel and colleagues describe an apparent solution to this problem by creating a model in which a MYC transgene containing a stop codon and flanking Ig kappa regulatory sequences is activated sporadically in germinal center B cells by AID-dependent somatic hypermutation that reverts the stop codon. Although much remains to be done to fully characterize this model, this approach is likely to impact the creation of sporadic models for other kinds of germinal center B cell tumors. |
