| First Author | Jiao J | Year | 2008 |
| Journal | PLoS One | Volume | 3 |
| Issue | 2 | Pages | e1684 |
| PubMed ID | 18301761 | Mgi Jnum | J:132882 |
| Mgi Id | MGI:3777080 | Doi | 10.1371/journal.pone.0001684 |
| Citation | Jiao J, et al. (2008) Expression of NR2B in Cerebellar Granule Cells Specifically Facilitates Effect of Motor Training on Motor Learning. PLoS One 3(2):e1684 |
| abstractText | It is believed that gene/environment interaction (GEI) plays a pivotal role in the development of motor skills, which are acquired via practicing or motor training. However, the underlying molecular/neuronal mechanisms are still unclear. Here, we reported that the expression of NR2B, a subunit of NMDA receptors, in cerebellar granule cells specifically enhanced the effect of voluntary motor training on motor learning in the mouse. Moreover, this effect was characterized as motor learning-specific and developmental stage-dependent, because neither emotional/spatial memory was affected nor was the enhanced motor learning observed when the motor training was conducted starting at the age of 3 months old in these transgenic mice. These results indicate that changes in the expression of gene(s) that are involved in regulating synaptic plasticity in cerebellar granule cells may constitute a molecular basis for the cerebellum to be involved in the GEI by facilitating motor skill learning. |
