| First Author | Bagchi A | Year | 2008 |
| Journal | Cancer Res | Volume | 68 |
| Issue | 8 | Pages | 2551-6 |
| PubMed ID | 18413720 | Mgi Jnum | J:133997 |
| Mgi Id | MGI:3784754 | Doi | 10.1158/0008-5472.CAN-07-2095 |
| Citation | Bagchi A, et al. (2008) The quest for the 1p36 tumor suppressor. Cancer Res 68(8):2551-6 |
| abstractText | Genomic analyses of late-stage human cancers have uncovered deletions encompassing 1p36, thereby providing an extensive body of literature supporting the idea that a potent tumor suppressor resides in this interval. Although several genes have been proposed as 1p36 candidate tumor suppressors, convincing evidence that their encoded products protect from cancer has been scanty. A recent functional study identified chromodomain helicase DNA-binding protein 5 (CHD5) as a novel tumor suppressor mapping to 1p36. Here, we discuss evidence supporting the tumor-suppressive role of CHD5. Together, these findings suggest that strategies designed to enhance CHD5 activity could provide novel approaches for treating a broad range of human malignancies. |
