| First Author | Viana R | Year | 2008 |
| Journal | Biochem Biophys Res Commun | Volume | 369 |
| Issue | 3 | Pages | 964-8 |
| PubMed ID | 18328803 | Mgi Jnum | J:134072 |
| Mgi Id | MGI:3784923 | Doi | 10.1016/j.bbrc.2008.02.126 |
| Citation | Viana R, et al. (2008) Role of AMP-activated protein kinase in autophagy and proteasome function. Biochem Biophys Res Commun 369(3):964-8 |
| abstractText | In this work, we have examined the possible role of AMP-activated protein kinase (a key energy sensor) in regulating intracellular protein degradation. We have found that AICAR, a known activator of AMPK, has a dual effect. On one hand, it inhibits autophagy by a mechanism independent of AMPK activity; AICAR decreases class III PI3-kinase binding to beclin-1 and this effect counteracts and reverses the known positive effect of AMPK activity on autophagy. On the other hand, AICAR inhibits the proteasomal degradation of proteins by an AMPK-dependent mechanism. This is a novel function of AMPK that allows the regulation of proteasomal activity under conditions of energy demand. |
