| First Author | Engelhardt JJ | Year | 2006 |
| Journal | J Immunol | Volume | 177 |
| Issue | 2 | Pages | 1052-61 |
| PubMed ID | 16818761 | Mgi Jnum | J:134946 |
| Mgi Id | MGI:3790139 | Doi | 10.4049/jimmunol.177.2.1052 |
| Citation | Engelhardt JJ, et al. (2006) CTLA-4 overexpression inhibits T cell responses through a CD28-B7-dependent mechanism. J Immunol 177(2):1052-61 |
| abstractText | CTLA-4 has been shown to be an important negative regulator of T cell activation. To better understand its inhibitory action, we constructed CTLA-4 transgenic mice that display constitutive cell surface expression of CTLA-4 on CD4 and CD8 T cells. In both in vivo and in vitro T cell responses, CTLA-4 overexpression inhibits T cell activation. This inhibition is dependent on B7 and CD28, suggesting that overexpressed CTLA-4 inhibits responses by competing with CD28 for B7 binding or by interfering with CD28 signaling. In addition, expression of the transgene decreases the number of CD25+Foxp3+ T cells in these mice, but does not affect their suppressive ability. Our data confirm the activity of CTLA-4 as a negative regulator of T cell activation and that its action may be by multiple mechanisms. |
