| First Author | Zohar O | Year | 2008 |
| Journal | J Immunol | Volume | 180 |
| Issue | 10 | Pages | 6447-51 |
| PubMed ID | 18453559 | Mgi Jnum | J:134965 |
| Mgi Id | MGI:3790158 | Doi | 10.4049/jimmunol.180.10.6447 |
| Citation | Zohar O, et al. (2008) Cutting edge: MHC class I-Ly49 interaction regulates neuronal function. J Immunol 180(10):6447-51 |
| abstractText | MHC class I molecules (MHC-I) have been implicated in nervous system development in the mouse. In this study we present evidence for the interaction of MHC-I with the NK cell receptor Ly49 in primary cortical neuronal cultures. We show that MHC-I and Ly49 are expressed on neuronal soma and axon surfaces, with Ly49 also present on dendrites. Anti-MHC-I Abs reduce synapsin-I expression and enhance neurite outgrowth and neuronal death. Conversely, anti-Ly49 mAbs increase synapsin-I expression, reduce neurite outgrowth, and promote neuron viability. Because we show that Ly49 genes are selectively expressed in the adult brain, these findings suggest an unsuspected role for the MHC-I-Ly49 interaction in the development and function of the brain. |
