| First Author | Dajas-Bailador F | Year | 2008 |
| Journal | Curr Biol | Volume | 18 |
| Issue | 3 | Pages | 221-6 |
| PubMed ID | 18261906 | Mgi Jnum | J:135306 |
| Mgi Id | MGI:3793368 | Doi | 10.1016/j.cub.2008.01.025 |
| Citation | Dajas-Bailador F, et al. (2008) The JIP1 scaffold protein regulates axonal development in cortical neurons. Curr Biol 18(3):221-6 |
| abstractText | The development of neuronal polarity is essential for the determination of neuron connectivity and for correct brain function. The c-Jun N-terminal kinase (JNK)-interacting protein-1 (JIP1) is highly expressed in neurons and has previously been characterized as a regulator of JNK signaling.JIP1 has been shown to localize to neurites in various neuronal models, but the functional significance of this localization is not fully understood [1-4]. JIP1 is also a cargo of the motor protein kinesin-1, which is important for axonal transport [2, 4]. Here we demonstrate that before primary cortical neurons become polarized, JIP1 specifically localizes to a single neurite and that after axonal specification,it accumulates in the emerging axon. JIP1 is necessary for normal axonal development and promotes axonal growth dependent upon its binding to kinesin-1 and via a newly described interaction with the c-Abl tyrosine kinase. JIP1associates with and is phosphorylated by c-Abl, and the mutation of the c-Abl phosphorylation site on JIP1 abrogates its ability to promote axonal growth. JIP1 is therefore an important regulator of axonal development and is a key target of c-Abl-dependent pathways that control axonal growth. |
