| First Author | Kim CH | Year | 2008 |
| Journal | Mol Cell Biol | Volume | 28 |
| Issue | 9 | Pages | 2941-51 |
| PubMed ID | 18316399 | Mgi Jnum | J:135813 |
| Mgi Id | MGI:3794496 | Doi | 10.1128/MCB.01682-07 |
| Citation | Kim CH, et al. (2008) Beta-catenin interacts with MyoD and regulates its transcription activity. Mol Cell Biol 28(9):2941-51 |
| abstractText | Wnt regulation of muscle development is thought to be mediated by the beta-catenin-TCF/LEF-dependent canonical pathway. Here we demonstrate that beta-catenin, not TCF/LEF, is required for muscle differentiation. We showed that beta-catenin interacts directly with MyoD, a basic helix-loop-helix transcription factor essential for muscle differentiation and enhances its binding to E box elements and transcriptional activity. MyoD-mediated transactivation is inhibited in muscle cells when beta-catenin is deficient or the interaction between MyoD and beta-catenin is disrupted. These results demonstrate that beta-catenin is necessary for MyoD function, identifying MyoD as an effector in the Wnt canonical pathway. |
