| First Author | Murphy SP | Year | 2008 |
| Journal | Brain Res | Volume | 1207 |
| Pages | 32-5 | PubMed ID | 18374309 |
| Mgi Jnum | J:136157 | Mgi Id | MGI:3795329 |
| Doi | 10.1016/j.brainres.2008.02.063 | Citation | Murphy SP, et al. (2008) Neuregulin signaling in neurons depends on ErbB4 interaction with PSD-95. Brain Res 1207:32-5 |
| abstractText | Neuregulin-1 signaling molecules have various roles in the nervous system, including effects on neuronal migration and differentiation. In mouse cerebellar granule neurons the effects of neuregulin-1 (type I) are mediated by a homo-dimeric ErbB4 receptor, which can interact with the PSD-95 protein through a C-terminal motif. To determine whether this interaction is critical for signaling we introduced into granule cells a decoy peptide representing the C-terminal 20 amino acids of the mouse ErbB4 receptor. Exposure of unloaded cells to neuregulin-1 did not alter neurite density but increased average neurite length by 50%. In contrast, granule cell cultures loaded with the decoy peptide were unresponsive to the ligand. We conclude that the association of ErbB4 with PSD-95 is important for neuregulin-induced neuronal differentiation. |
