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Publication : Wnt signalling and its impact on development and cancer.

First Author  Klaus A Year  2008
Journal  Nat Rev Cancer Volume  8
Issue  5 Pages  387-98
PubMed ID  18432252 Mgi Jnum  J:136295
Mgi Id  MGI:3795838 Doi  10.1038/nrc2389
Citation  Klaus A, et al. (2008) Wnt signalling and its impact on development and cancer. Nat Rev Cancer 8(5):387-98
abstractText  The Wnt signalling pathway is an ancient system that has been highly conserved during evolution. It has a crucial role in the embryonic development of all animal species, in the regeneration of tissues in adult organisms and in many other processes. Mutations or deregulated expression of components of the Wnt pathway can induce disease, most importantly cancer. The first gene to be identified that encodes a Wnt signalling component, Int1 (integration 1), was molecularly characterized from mouse tumour cells 25 years ago. In parallel, the homologous gene Wingless in Drosophila melanogaster, which produces developmental defects in embryos, was characterized. Since then, further components of the Wnt pathway have been identified and their epistatic relationships have been defined. This article is a Timeline of crucial discoveries about the components and functions of this essential pathway.
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