| First Author | Ogawa K | Year | 2008 |
| Journal | J Leukoc Biol | Volume | 83 |
| Issue | 6 | Pages | 1451-8 |
| PubMed ID | 18353928 | Mgi Jnum | J:136805 |
| Mgi Id | MGI:3797151 | Doi | 10.1189/jlb.1007710 |
| Citation | Ogawa K, et al. (2008) A dual role of activin A in regulating immunoglobulin production of B cells. J Leukoc Biol 83(6):1451-8 |
| abstractText | Here, we report that activin A has a dual role in regulating Ig production of murine B cells. Activated B cells secrete activin activity by increasing activin A and decreasing follistatin expression. B cells also express type I and type II activin receptors, suggesting that they are targets of activin. Pretreatment of naive B cells with activin A and subsequent activation by LPS resulted in increased cell growth and IgG production. In contrast, no significant effect was observed when activin A was added to naive B cells simultaneously with LPS, indicating that activin A acts on resting but not activated B cells. In addition, activin A did not induce B cells to produce IgE, even when added prior to activation; however, in vivo antigen-specific IgE production was reduced significantly by neutralization of circulating activin A. These findings indicate that activin A plays an important role in Th2-mediated immune responses by enhancing antibody production through two distinct modes: acts directly on resting B cells to elicit full functions of activated B cells and acts indirectly on activated B cells through modulation of other immune cells. |
