| First Author | Reynaud D | Year | 2008 |
| Journal | Nat Immunol | Volume | 9 |
| Issue | 8 | Pages | 927-36 |
| PubMed ID | 18568028 | Mgi Jnum | J:137686 |
| Mgi Id | MGI:3801526 | Doi | 10.1038/ni.1626 |
| Citation | Reynaud D, et al. (2008) Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros. Nat Immunol 9(8):927-36 |
| abstractText | The transcription factor Ikaros is essential for B cell development. However, its molecular functions in B cell fate specification and commitment have remained elusive. We show here that the transcription factor EBF restored the generation of CD19(+) pro-B cells from Ikaros-deficient hematopoietic progenitors. Notably, these pro-B cells, despite having normal expression of the transcription factors EBF and Pax5, were not committed to the B cell fate. They also failed to recombine variable gene segments at the immunoglobulin heavy-chain locus. Ikaros promoted heavy-chain gene rearrangements by inducing expression of the recombination-activating genes as well as by controlling accessibility of the variable gene segments and compaction of the immunoglobulin heavy-chain locus. Thus, Ikaros is an obligate component of a network that regulates B cell fate commitment and immunoglobulin heavy-chain gene recombination. |
