| First Author | Arikkath J | Year | 2008 |
| Journal | J Neurosci | Volume | 28 |
| Issue | 28 | Pages | 7047-56 |
| PubMed ID | 18614673 | Mgi Jnum | J:138014 |
| Mgi Id | MGI:3803550 | Doi | 10.1523/JNEUROSCI.0451-08.2008 |
| Citation | Arikkath J, et al. (2008) Erbin controls dendritic morphogenesis by regulating localization of delta-catenin. J Neurosci 28(28):7047-56 |
| abstractText | The LAP [leucine-rich and postsynaptic density-95/Discs large/zona occludens-1 (PDZ)] protein erbin and delta-catenin, a component of the cadherin-catenin cell adhesion complex, are highly expressed in neurons and associate through PDZ-mediated interaction, but have incompletely characterized neuronal functions. We show that short hairpin RNA-mediated knockdown of erbin and knockdown or genetic ablation of delta-catenin severely impaired dendritic morphogenesis in hippocampal neurons. Simultaneous loss of erbin and delta-catenin does not enhance severity of this phenotype. The dendritic phenotype observed after erbin depletion is rescued by overexpression of delta-catenin and requires a domain in delta-catenin that has been shown to regulate dendritic branching. Knockdown of delta-catenin cannot be rescued by overexpression of erbin, indicating that erbin is upstream of delta-catenin. delta-Catenin-null neurons have no alterations in global levels of active Rac1/RhoA. Knockdown of erbin results in alterations in localization of delta-catenin. These results suggest a critical role for erbin in regulating dendritic morphogenesis by maintaining appropriate localization of delta-catenin. |
