| First Author | Logue EC | Year | 2006 |
| Journal | J Immunol | Volume | 177 |
| Issue | 4 | Pages | 2356-64 |
| PubMed ID | 16887997 | Mgi Jnum | J:138390 |
| Mgi Id | MGI:3805095 | Doi | 10.4049/jimmunol.177.4.2356 |
| Citation | Logue EC, et al. (2006) ICOS-induced B7h shedding on B cells is inhibited by TLR7/8 and TLR9. J Immunol 177(4):2356-64 |
| abstractText | We report in this study that B7h, the ligand for the ICOS costimulatory receptor, is rapidly shed from mouse B cells following either ICOS binding or BCR engagement. Shedding occurs through proteolytic cleavage that releases the extracellular ICOS-binding region of B7h. Prior exposure of B7h-expressing APCs to ICOS-expressing cells inhibits their subsequent ability to costimulate IFN-gamma and IL-4 production from CD4+ T cells. Shedding is regulated as TLR7/8 and TLR9 ligands inhibit B7h shedding. A shedding-resistant B7h mutant elicits greater costimulation of IFN-gamma production from CD4+ T cells than does wild-type B7h. These data define shedding of B7h as a novel mechanism for controlling costimulatory signaling by B7-CD28 family members that is regulated on B cells by TLR signaling. |
