| First Author | Zhou J | Year | 2008 |
| Journal | Nat Neurosci | Volume | 11 |
| Issue | 7 | Pages | 741-3 |
| PubMed ID | 18516035 | Mgi Jnum | J:139372 |
| Mgi Id | MGI:3807824 | Doi | 10.1038/nn.2127 |
| Citation | Zhou J, et al. (2008) Critical role of TRPC6 channels in the formation of excitatory synapses. Nat Neurosci 11(7):741-3 |
| abstractText | The transient receptor potential canonical (TRPC) channels are Ca2+-permeable, nonselective cation channels with different biological functions, but their roles in brain are largely unknown. Here we report that TRPC6 was localized to excitatory synapses and promoted their formation via a CaMKIV-CREB-dependent pathway. TRPC6 transgenic mice showed enhancement in spine formation, and spatial learning and memory in Morris water maze. These results reveal a previously unknown role of TRPC6 in synaptic and behavioral plasticity. |
