| First Author | May KF Jr | Year | 2007 |
| Journal | Blood | Volume | 109 |
| Issue | 1 | Pages | 253-8 |
| PubMed ID | 16896159 | Mgi Jnum | J:142179 |
| Mgi Id | MGI:3820498 | Doi | 10.1182/blood-2006-01-031278 |
| Citation | May KF Jr, et al. (2007) Immune competence of cancer-reactive T cells generated de novo in adult tumor-bearing mice. Blood 109(1):253-8 |
| abstractText | The impact of timing of antigen introduction into fetus and neonates leads to the suggestion that pre-existing antigens are tolerogenic to immunocompetent cells generated thereafter. This hypothesis predicts that in patients with cancer who are undergoing bone marrow transplantation, newly produced T cells with specificity for pre-existing tumor cells will be inactivated by the tumor antigens in the host. Because the effect of tumor cells on developing cancer-reactive T cells has not been investigated, we set out to systematically analyze the impact of tumor cells in the periphery on the development of tumor-reactive T cells in the thymus and their immunocompetence in the periphery. Our data demonstrate that in the host in which a tumor is established in the periphery, the cancer-reactive T cells develop normally, remain fully immunocompetent, become activated in the periphery, and cause regression of large established tumors. The immunocompetence of T cells generated in an antigen-bearing host is also confirmed in a skin graft transplantation model. |
