| First Author | Tjwa M | Year | 2008 |
| Journal | Blood | Volume | 112 |
| Issue | 10 | Pages | 4048-50 |
| PubMed ID | 18723692 | Mgi Jnum | J:142267 |
| Mgi Id | MGI:3820792 | Doi | 10.1182/blood-2008-07-166587 |
| Citation | Tjwa M, et al. (2008) Plasmin therapy enhances mobilization of HPCs after G-CSF. Blood 112(10):4048-50 |
| abstractText | The role of proteinases in the mobilization of hematopoietic progenitor cells (HPCs) after granulocyte colony-stimulating factor (G-CSF) remains unclear. Here we report that genetic loss of the plasminogen activator inhibitor Pai-1 or of the plasmin inhibitor alpha2-antiplasmin increases HPC mobilization in response to G-CSF. Moreover, thrombolytic agents, such as tenecteplase and microplasmin, enhance HPC mobilization in mice and humans. Taken together, these findings identify a novel role for plasmin in augmenting HPC mobilization in response to G-CSF. |
