| First Author | Al-Salihi MA | Year | 2009 |
| Journal | Cancer Lett | Volume | 273 |
| Issue | 2 | Pages | 225-32 |
| PubMed ID | 18790560 | Mgi Jnum | J:142762 |
| Mgi Id | MGI:3822101 | Doi | 10.1016/j.canlet.2008.08.012 |
| Citation | Al-Salihi MA, et al. (2009) Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient to initiate tumorigenesis but promotes tumor progression. Cancer Lett 273(2):225-32 |
| abstractText | We generated mice expressing a COX-2 transgene in colon epithelium and found that they did not develop spontaneous colon tumors. But when treated with azoxymethane, a colon carcinogen, COX-2 mice had a higher tumor load compared to wild-type mice. There was no change in the number of pre-neoplastic lesions, indicating that COX-2 does not affect tumor initiation. Tumors in the COX-2 transgenic mice had higher levels of phosphorylated epidermal growth factor receptor and Akt compared to wild-type mice. Collectively, our data indicate that COX-2 promotes colon tumor progression, but not initiation, and it does so, in part, by activating EGFR and Akt signaling pathways. |
